Eliminating or reducing the activity of HUWE1 itself, which reduces WNT/CTNNB1 signaling in WT HAP1–7TGP, CSNK1A1KO and CTNNB1ST-A cells, is unlikely to be a viable therapeutic strategy due to the pleiotropic effects of HUWE1 on cell physiology, including tumor suppressor functions [39]. The gene discussed is CTNNB1; the disease is neoplasm.