The following covariates were reported as significant, only appearing in one study: cholinesterase; CNS infection; day after burn injury; dialysis (verbatim covariate used in one study for type of dialysis used); factor V; heart rate; hydrogen carbonate; indwelling catheter; lactate; Model for End-Stage Liver Disease score; mode of administration (of study drug); shock; and uric acid. The gene discussed is BCHE; the disease is End Stage Liver Disease.