In patients with ICI-myocarditis, hs-cTnI has been noted to rise and fall more rapidly than cTnT (39), leading to recommendations for its preferential use in the initial assessment and diagnosis of ICI-myocarditis (10, 11), with cTnT having additional prognostic and potentially diagnostic utility for skeletal muscle myotoxicity. This evidence concerns the gene TNNI3 and myocarditis.