The present investigation clearly showed that the expression of KCNK1/TWIK1 and KCNK2/TREK1 channels was up-regulated in PASMCs from IPAH patients, MCT-PH rats, SuHx-PH rats, and hypoxia-PH mice. Here, KCNK1 is linked to idiopathic pulmonary arterial hypertension.