The present investigation demonstrated that the expression of KCNK1/TWIK1 and KCNK2/TREK1 channels was up-regulated in PASMCs from IPAH patients and experimental PH animals and their up-regulation facilitated the proliferation and migration of IPAH-PASMCs via enhanced Ca2+ signaling and JNK signaling pathway, resulting in vascular remodeling in PAH. The gene discussed is KCNK2; the disease is idiopathic pulmonary arterial hypertension.