Therefore, membrane hyperpolarization due to the up-regulation of KCNK1/KCNK2 channel expression facilitates Ca2+ influx through ROC and SOC channels in IPAH-PASMCs, similar to that in non-excitable cells, such as epithelial, endothelial, immune, and cancer cells (34). The gene discussed is KCNK1; the disease is cancer.