More than 1,000 variants in genes, including SLC26A4 (OMIM 605646), CDH23 (OMIM 601067), GJB2 (OMIM 220290), STRC (OMIM 606440), and OTOF (OMIM 603681), have been found to be associated with non-syndromic HL (Chari and Chan, 2017). The gene discussed is GJB2; the disease is Hodgkins lymphoma.