MGMT and glioblastoma: For instance, aggressive surgical intervention could be proposed more strongly for MGMT promotor unmethylated (pMGMT-unmet) than for pMGMT-met GBM patients due to the expected minimal benefit from temozolomide.5 In contrast, an optimal balance between maximal resection and preservation of the patient’s quality of daily life could be considered for pMGMT-met GBM patients.