MGMT and glioblastoma: A recently published article, which focuses on MRI-based prediction of GBM’s MGMT methylation status powered by deep learning models, highlights the profound difficulty of achieving this task.32 In contrast to previous studies, the current research takes a different approach by attempting to identify a subgroup of GBM where the MGMT methylation status can be readily discerned rather than solely focusing on the overall prediction accuracy of the diagnostic model.