PLEC and oral cavity squamous cell carcinoma: Moreover, the overexpression of KRT17 is correlated with unfavorable OS and reduced responsiveness to platinum-based therapy in patients diagnosed with oral squamous cell carcinoma The interaction between KRT17 and plectin (a macromolecular cytoskeletal protein) triggers the activation of the integrin β4/FAK/ERK pathway, thereby facilitating the stabilization and nuclear translocation of β-catenin while augmenting oral squamous cell carcinoma stemness and CD44 expression (Jang et al., 2022).