PTK2 and neoplasm: However, studies by Marina Roy-Luzarraga et al. found that inducing endothelial FAK deficiency in both orthotopic and spontaneous mouse model of pancreatic ductal adenocarcinoma (PDA) did not hinder angiogenesis but reduced the incidence of tumor metastasis and improved mouse survival (Roy-Luzarraga et al., 2022).