Yin et al. found that ATP-binding cassette subfamily G member 1 mediates the signaling of extracellular matrix protein-1-integrin αXβ2 interaction, leading to the activation of FAK/Rho/cytoskeleton molecules and conferring cisplatin resistance on cancer cells by upregulating CD326-mediated stemness (Yin et al., 2021). Here, PTK2 is linked to cancer.