As a crucial upstream regulator of the PI3K/AKT pathway, FAK activates PI3K/AKT and its related downstream effectors, including mTOR, β-catenin and p53, promoting cancer progression (Claesson-Welsh and Welsh, 2013; Sulzmaier et al., 2014; Guo et al., 2020). This evidence concerns the gene TP53 and cancer.