Lakshmanan et al. developed two genetically engineered lung cancer mouse models KrasG12D/+; Trp53R172H/+; Ad-Cre (KPA) and KrasG12D/+; Ad-Cre (KA), revealing the ST6GalNAc-1/MUC5AC axis as a mediator of mutant p53’s regulation of FAK signal transduction. This evidence concerns the gene PTK2 and lung carcinoma.