Other DAPs upregulated in PR (CAD, RALB, FAM120A, PSMC2, LRPPRC, PARP1, PSMB5, ANP32B, IMPDH2, XRCC5, TPD52L2, EIFA5A, DDT, GNB1, HDGF, and MYO1C) were associated with metabolic activity in rectal tumor tissue (18). This evidence concerns the gene IMPDH2 and rectal neoplasm.