TBX21 and cutaneous melanoma: In an inflammatory environment, IFN-γ triggers the activation of the immune response and stimulates the elimination of pathogens, while also preventing over-activation of the immune system and tissue damage44 TBX21 has also been found to be involved in immunological processes, and increased expression of TBX21 has been associated with better prognosis in skin cutaneous melanoma, they can influence the Th1/Th2 immune balance31,45.