Furthermore, baseline levels of Rab9 protein were found to be significantly lower in neurons derived from patients with PD caused by the Miro1 R272Q mutation, suggesting that pathological changes in alternative autophagy may be evident in both Miro1 R272Q mutant and VPS35 D620N mutant models of monogenic PD [40]. The gene discussed is RHOT1; the disease is Parkinson disease.