Mutations in the ERBB2 gene (p.(Leu755Ser) in two, p.(Arg784His) in two, and one case each of p.His295AspfsTer16, p.(Val762Leu), p.(Val777Leu), and p.(Val842Ile)) were detected in 8 (1.4%) of the 552 CRC cases analyzed. Here, ERBB2 is linked to colorectal carcinoma.