Next, to overcome the limitations of the number of insulin-positive β-cells being drastically decreased in established T1D, we intersected the differentially m6A decorated genes with the β-cell transcriptome from a sc-RNA seq dataset performed in islets from established T1D patients and non-diabetic controls (GSE121863) (Fig. 6k and Extended Data Fig. 6a). The gene discussed is INS; the disease is type 1 diabetes mellitus.