To begin to dissect the mechanism(s) involved in the dynamic regulation of METTL3 during T1D progression, we considered recent findings reporting increased accumulation of intracellular ROS prior to the development of T1D53, 59 and the upregulation of ER-stress markers in human T1D β-cells60, 61. Here, METTL3 is linked to type 1 diabetes mellitus.