For example, rs78378222 in the 3′UTR of TP53 alters the canonical polyadenylation signal from AATAAA to AATACA; this impairs 3′-end processing of TP53 mRNA, altering susceptibility to multiple cancers, including cutaneous basal cell carcinoma, prostate cancer, glioma, and colorectal adenoma22. This evidence concerns the gene TP53 and central nervous system cancer.