For example, rs78378222 in the 3′UTR of TP53 alters the canonical polyadenylation signal from AATAAA to AATACA; this impairs 3′-end processing of TP53 mRNA, altering susceptibility to multiple cancers, including cutaneous basal cell carcinoma, prostate cancer, glioma, and colorectal adenoma22. Here, TP53 is linked to glioma.