RPAIN and breast cancer: We also selected three other top-ranked putative breast cancer APA-linked susceptibility genes-autocrine motility factor receptor (AMFR), RPA-interacting protein (RPAIN), autophagy related 10 (ATG10) (Fig. S22a–c) and observed consistent results that alterations in alternative 3′UTR of these genes could affect protein abundance (Fig. S22d–f) and cellular proliferation (Fig. S22g–l).