Interestingly, our 3′aTWAS identified multiple known cancer risk genes, such as small G protein signaling modulator 3 (SGSM3)44, which is significantly associated with breast cancer in breast mammary tissue (P3’aTWAS = 2.6 × 10−18, PeTWAS = 0.47, PsTWAS = 0.40). The gene discussed is SGSM3; the disease is cancer.