In addition to the hypomethylating effects of 5-Aza treatment in astrocytes, we observed a decrease in Hbegf promoter methylation in cells obtained from circulating cells, indicating that the epigenetic regulation of HB-EGF in response to autoimmune inflammation may not be specific to the CNS (Fig. 6o and Extended Data Fig. 7m). Here, HBEGF is linked to inflammation.