In three independent experiments, we consistently found that both tumor volume (Fig. 3A and Supplementary Fig. S3A) and tumor weight were lower (by 34%, p = 0.034) (Fig. 3B) in the macrophage-specific Phgdh-knockout mice (8–12 weeks) than in the control mice (8–12 weeks) and corresponded to a significant reduction in TAM (CD45+CD11b+F4/80+) infiltration (Fig. 3C and Supplementary Fig. S3B). This evidence concerns the gene PHGDH and neoplasm.