NOS2 and neoplasm: We found that compared with TAMs from Phgdhfl/fl tumor-bearing mice, those from Phgdhfl/flCx3cr1-Cre tumor-bearing mice exhibited significant upregulation of genes linked to an M1-like/proinflammatory phenotype (Nos2 and Tnfa) (Fig. 3E), while downregulated genes were associated with an M2-like/protumorigenic phenotype (Arg1, Tgfb and Il10) (Fig. 3F).