Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis found that genes involved in the NOD-like receptor signaling pathway, necroptosis, hypertrophic cardiomyopathy, and dilated cardiomyopathy were upregulated in hearts of MARCH2 KO mice subjected to I/R injury (Fig. 3b). This evidence concerns the gene MARCHF2 and hypertrophic cardiomyopathy.