For progression-free survival (PFS), SAA (HR 2.54; 95% CI, 1.27–5.06; P = 0.006) and tumor marker-PIVKA-II (HR 2.23; 95% CI, 1.13–4.42; P = 0.018) were potential prognostic factors (Supplementary Fig. 2b). This evidence concerns the gene SAA1 and neoplasm.