CD8A and hepatocellular carcinoma: By comparing the co-expression of SAA and infiltrating immune cells between high and low SAA HCC peritumor TMA in local samples (n = 160), neutrophils (CD15+) (P < 0.0001), and macrophages (CD68+) (P < 0.01) were significantly increased, while CD8+ T cells were significantly decreased in the SAA-high cohort (Fig. 2a and Supplementary Fig. 8c).