On the other hand, the stromal capacity to shape macrophages might be of interest to explore in the pathologic immunosuppressive context as well since high levels of PDL1 have been described as a biomarker for a poor prognosis in colorectal cancer (especially in tumors with microsatellite instability)50, and the primary source of PDL1 in colorectal cancer is tumor-associated CD14+ monocytes/macrophages51. This evidence concerns the gene CD274 and colorectal cancer.