NUCLEOLIN and myocardial infarction: In addition to our data demonstrating that Nucleolin depletion compromises the viability of cardiomyocytes, others have observed that Nucleolin protects myocytes against cell death induced by hypoxia or oxidative injury [14, 17] and in models of acute MI and I/R injury, Nucleolin down-regulation is associated with impaired cardiac function [14, 15].