These distinct and sometimes diametrically opposed actions of R7 family members have important implications in the clinical context as, while inhibition of either RGS6 or RGS7 may be cardioprotective, RGS6, but not RGS7 is required for the cancer killing actions of doxorubicin [24, 29] and functions as a tumor suppressor in bladder and breast cancers [62, 63]. The gene discussed is RGS6; the disease is cancer.