Collagen PTMs include those formed by lysyl oxidase (LOX) and prolyl 3 hydroxylases (P3H), help to direct collagen self-assembly, crosslinking, and fibril structure.54–58 Accordingly, collagen PTMs underpin bone quality and contribute to fragility in aging, diabetes, and osteogeneses imperfecta, where specific PTMs are suppressed.55,57,59. The gene discussed is P3H3; the disease is diabetes mellitus.