Collagen PTMs include those formed by lysyl oxidase (LOX) and prolyl 3 hydroxylases (P3H), help to direct collagen self-assembly, crosslinking, and fibril structure.54–58 Accordingly, collagen PTMs underpin bone quality and contribute to fragility in aging, diabetes, and osteogeneses imperfecta, where specific PTMs are suppressed.55,57,59. Here, LOX is linked to diabetes mellitus.