NINJ1 and Yersinia infectious disease: While previous studies have found that NINJ1 is not responsible for membrane permeability to allow the uptake of YOYO-1 or the release of IL-1β44, others have found that PI and other molecules can pass through the NINJ1 pore in response to Yersinia infection or staurosporine treatment55, consistent with our observations in the context of HS here.