Together with what we found in CML that Bim binds to a pool of Hsp70, which accounts for only a small part of total Hsp70, but it recruits a specific group of CML addicted clients, we identified conformational-dependent Hsp70/Bim/clients complex. The gene discussed is HSPA1A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.