In this study, we found that overexpression of PPP2R2B suppressed the expressions of N‐cadherin, β‐catenin and MMP‐9 and while promoting the expression of E‐cadherin, suggesting PPP2R2B overexpression promoted BC progression via suppressing Wnt/β‐catenin/EMT pathway. The gene discussed is CDH2; the disease is breast cancer.