Histone modifications have been found to play a role in the activation of the NLRP3 inflammasome and subsequently in the manifestation of multiple autoimmune and autoinflammatory disorders, such as systemic lupus erythematosus [47], rheumatoid arthritis [48], Behçet disease (BD) [49], atherosclerosis, and Alzheimer’s disease [50]. The gene discussed is NLRP3; the disease is Behcet disease.