Therefore, although colchicine has been used as the gold standard treatment for FMF since the 1970s [26], colchicine-resistant patients are administered IL-1β inhibitors such as anakinra (an IL-1 receptor antagonist) and canakinumab (a human monoclonal anti-IL-1β antibody) [27, 28]. The gene discussed is IL1B; the disease is familial Mediterranean fever.