VEGFA and neoplasm: As illustrated in Fig. 5E, the number of Tregs in the TME of mice administered aPD-1-PLTM-HMSNs@Sora was significantly reduced in comparison with that of aPD-1 + Sora, which may be related to the inhibition of VEGF-A production by high accumulation of Sora in local tumor areas (Fig. 4E).