CDKN1B was significantly higher in the homogenized femora from mice with bone-disseminated tumor cells that expressed PTHrP lacking the NLS and C-terminal domain only (Fig. 5A), confirming that even in the distant metastatic site, the truncated form of PTHrP induces more p27 in tumor cells than other PTHrP peptides. The gene discussed is CDKN1B; the disease is neoplasm.