In conclusions, this research suggests that EGR1-mediated upregulation of MDR1 play a crucial role in the induction of gemcitabine resistance in pancreatic cancer cells.EGR1 is a nuclear protein that acts as a transcriptional regulator of a variety of genes, including tumor suppressor genes and oncogenes. The gene discussed is EGR1; the disease is familial pancreatic carcinoma.