Therefore, understanding the molecular mechanisms of gemcitabine resistance is essential to improve treatment strategies for pancreatic cancer.Several reports have confirmed that EGR1, as a transcription factor [32], is involved in regulating a variety of cellular processes, including proliferation, differentiation, angiogenesis, apoptosis, tumor invasion, and metastasis [6, 33]. The gene discussed is EGR1; the disease is neoplasm.