CYP2C19 and ischemic stroke: In addition, for the two common polymorphic loci rs12248560 and rs4244285 of CYP2C19, the genotype of rs12248560 was associated with decreased breast cancer risk (aOR = 0.77, 95% CI: 0.65–0.93) [41], while rs4244285 polymorphism was related to higher risk of epilepsy (aOR = 4.24, 95% CI: 2.52–7.15) [42], long-term ischemic stroke events (hazard ratio: 1.64, 95% CI: 1.06–2.53) [43], hypertension (aOR = 2.433, 95% CI: 1.797–3.293) [44].