The lead variant in the lean PCOS meta-analysis, rs12000707 (Fig. 1; Supplementary Table 1), is a non-coding intronic variant that has not previously been highlighted by GWAS but does have GTEx data supporting a role as an expression quantitative trait locus (eQTL) in subcutaneous adipose tissue (DENND1A; P = 7.0 × 10–6) [13]. Here, DENND1A is linked to polycystic ovary syndrome.