SHBG and polycystic ovary syndrome: Indeed, principal component analysis has demonstrated clusters of risk factors explaining the variance in PCOS – involving women with i) high BMI, insulin resistance, low high-density lipoprotein and low sex hormone binding globulin, ii) hypertension, elevated low-density lipoprotein and hypertriglyceridemia and iii) a lean PCOS phenotype with elevated luteinizing hormone: follicle stimulating hormone ratio and total testosterone [11].