Besides glycemic control and promotion of weight loss among diabetes and non-diabetes populations [7–12], existing clinical trials and previous systematic reviews also illustrated that GLP1-RAs have further benefits on change in body composition and anthropometric indices (i.e., visceral, subcutaneous, epicardial fat mass, BMI, and waist circumference) [8, 12–15]. The gene discussed is GLP1R; the disease is diabetes mellitus.