IL1A and neoplasm: During the differentiation of mononuclear phagocytes, the expression of inflammatory genes (TNF, IL1A, IL1B, IL23A) and immunosuppression-related genes (CD86, LILRB4, CD274 [25] PDCD1LG2) was gradually decreased and increased, respectively (Figs 4D and S5B), indicating that the immune function of mononuclear phagocytes decreases towards forming an immunosuppressive tumor microenvironment.