SMAD4 and lung cancer: Since APC, KRAS, SMAD4, and CDKN1B are \commonly mutated genes in CRC and mCRC, and KMT2C mutations have been associated with metastasis and poor survival in patients with lung cancer [65, 66], CWH22 and CLM22 are representative CRC cell lines with mutated APC/KRAS/SMAD4/CDKN1B/KMT2C genes and wild-type TP53 and PIK3CA.