RBPJ and ischemia: Notch-RBP-J signaling has been shown to play a role in regulating functional polarization and activation of macrophages, and regulated formation of Kupffer cells and macrophage differentiation from Ly6Chi monocytes in ischemia (Foldi et al., 2016; Hu et al., 2008; Kang et al., 2020; Krishnasamy et al., 2017; Sakai et al., 2019; Wang et al., 2010; Xu et al., 2012).