Both our study and the study by Michelini et al. identified genetic variants in the POMC gene, which has been linked to obesity predisposition.10,13 We identified a missense mutation (NC_000002.12:g.25161709G>A, rs752644128) that was predicted to be deleterious, while Michelini et al. detected a truncating variant (NC_000002.12:g.25161269C>A, rs202127120).10 Two of the genes contained in the lipedema panel and identified in our analysis, STAB1 and TNXB, are associated with the extracellular matrix (ECM), in line with the overrepresentation of microfibril binding from the GO analysis. Here, POMC is linked to obesity due to melanocortin 4 receptor deficiency.