However, recent studies found that GJB3 c.538C>T had a low prevalence in China and compared HL cases with normal hearing cases, carrier frequency of GJB3 c.538C>T differed not significantly (0.38%:0.24%, p > 0.05) (Chen et al., 2014; Huang et al., 2017). This evidence concerns the gene GJB3 and Hodgkins lymphoma.