ARHGEF39 and neoplasm: Four of these patients (P1-P4) suffered from sporadic PCCs: whole exome sequencing (WES) of these tumor tissues detected somatic mutations as compared with their adjacent normal adrenal medullary tissues, including in JAK2, ARHGEF39, KMT2D, and MST1 (Supplementary file 1a); note that none of these fit into the three previously molecularly defined groups in the TCGA molecular taxonomy (Crona et al., 2017).