PNMT and neoplasm: When considering clinical information from five PCC patients, including tumor size, signs, symptoms and laboratory tests, we observed that P4 exhibited relatively higher blood pressures and the plasma levels of 3-methoxytyramine and normetanephrine compared to P1-P3 and P5 (Supplementary file 1c), consistent with the high expression of PNMT in the kinase-type PCC patient (Figure 4E).