CD4 and neoplasm: Further analysis of immune cell type composition in metabolism-type and kinase-type PCCs showed an increase in the proportion of CD4+ T cells, CD8+ T cells, and M1 macrophages in tumor tissues as compared with that in adjacent normal adrenal medullary tissues, while the proportion of M2 macrophages in adjacent normal adrenal medullary tissues decreased as compared with that in tumor tissues (Figure 7F).