NOTCH1 and Alzheimer disease: Similarly, forthe Reactome, we identified 114, 58, and 293 significantly enrichedterms corresponding to Aβ1–42-associated plasma miRNAs,P-tau181-associated plasma miRNAs, and Aβ1–42-associatedserum miRNAs (Table S2), respectively,including AD-relevant pathways, e.g., PI3K, FOXO, cellular senescence,NOTCH1, etc. In our GO term enrichment analysis, we successfully identifieda multitude of enriched terms for Aβ1–42-associated plasmamiRNAs, P-tau181-associated plasma miRNAs, and Aβ1–42-associatedserum miRNAs, specifically 390, 583, and 769 terms, respectively (Table S3).