There is mounting evidence suggestionthat type 2 diabetes is associated with cognitive dysfunction, andindividuals with diabetes have been reported to have an elevated riskof developing various forms of dementia, including AD.68 MiR-145-5p has also been reported to be downregulatedin CSF of AD patients; however, no consistent result has been foundacross cohorts.69 In our study, we suggestedthe potential of miR-145-5p as a diagnostic biomarker for AD via ROCanalysis and validation datasets and its largest interactions withinthe PI3K/AKT signaling process (Figure 3). This evidence concerns the gene AKT1 and diabetes mellitus.