MAPT and Alzheimer disease: For instance, the increase ofGSK-3β activity is related to the increase of Aβ productionand deposition, hyperphosphorylation of tau, and the formation ofneurofibrillary tangles.63 Additionally,PI3K/AKT signaling can also regulate neuronal synaptic plasticityand memory processes.58,63,64 In this study, the identified circulating miRNAs all target thispathway, which suggested a role for these miRNAs in AD developmentand progression.