EPHX2 and osteoarthritis, knee: Previously, we reported an association between knee osteoarthritis progression and levels of 8,9-, 11,12-, and 14,15-DHET22 as well as positive correlations/associations with osteoarthritis knee pain.7 Although we cannot infer any causation, our data lend further support to a potential role of the sEH pathway in the persistence of knee pain.