REN and Hyperglycemia: According to earlier research, hyperglycemia and increased renin-angiotensin system (RAS) activity are the two main pathogenic factors that cause the endocannabinoid/cannabinoid1 receptor (CB1R) system to become overactive in podocytes, which in turn contributes to the development of diabetes and its complications [5, 20] and has detrimental effects on the body [20].