Disturbance of the angiopoietin/tyrosine kinase with immunoglobulin-like and VEGF-like domains 2 (Ang/Tyrosine Kinase with Immunoglobulin-like and EGF-like Domains (TIE2) pathways may cause endothelial activation and lead to sepsis [2]. The gene discussed is VEGFA; the disease is Sepsis.