Regulation of the NF-κB and NLRP3 inflammasome offers promising pharmaceutical options for treatment of inflammatory diseases including those induced by bacterial infections (Chernikov et al., 2021; Leszczyńska, Jakubczyk & Górska, 2022; Swanson, Deng & Ting, 2019; Zhang et al., 2021). The gene discussed is NFKB1; the disease is bacterial infectious disease.