Pan et al. (2013) demonstrated that patients with negative GRHPR had a significantly shorter survival time than those with positive GRHPR, indicating GRHPR deficiency in noncancerous tissues may be an independent biomarker of worse survival for HCC patients after curative resection. Song et al. (2020) found that peroxisomal coenzyme A diphosphatase NUDT7 deletion promotes the development of KrasG12D CRC. The gene discussed is GRHPR; the disease is hepatocellular carcinoma.