MX1 was reported to be changed as an antiviral gene and immune response factor in patients with hypogammaglobulinemia (Wirz et al., 2020), lupus nephritis (Cao et al., 2020), Zika virus infection (Anderson et al., 2021), lupus erythematosus (Xiang et al., 2021) and so on. The gene discussed is MX1; the disease is lupus nephritis.