PARP1 and acute myeloid leukemia: Moreover, the orphan snoRNA SNORA73 can combine with PARP-1 and the H/ACA box RNP core proteins DKC1/NHP2 to form a snoRNP at DNA damage genomic loci, which blocks PARP-1 autoPARylation and DNA damage repair and leads to genome instability and cell differentiation in acute myeloid leukemia (51).