SAMHD1 and cancer: Mutations and dysregulation of a sterile alpha motif (SAM) and histidine-aspartic acid (HD) domain-containing protein 1 (SAMHD1) are associated with Aicardi Goutières syndrome (AGS) (9), an inherited autoimmune encephalopathic disorder, and several cancers (10), including leukemias (11–13), lymphomas (14–16), colorectal cancer (17), and lung cancer (18).