SAMHD1 and diffuse large B-cell lymphoma: On multivariate Cox regression analysis controlling for stage, treatment, age at diagnosis, and IPI, low SAMHD1 expression remained significantly associated with better OS (HR: 3.42 (95% CI: 1.49–7.83); P= 0.004) (Table 3), indicating that SAMHD1 expression is an independent OS determinant for DLBCL patients in this cohort.