T2DM patients with microvascular complications had a statistically significant higher duration of diabetes, waist circumference, BMI, diastolic and systolic and blood pressure, serum creatinine, UACR, serum urea, TC, TG, LDL cholesterol, fasting plasma glucose (169.97±80.4 versus 128.72±26.9 mg/dL), and postprandial plasma glucose (279.7±110.4 versus 242.3±56.3 mg/dL), while they had statistically significant lower eGFR, HDL cholesterol, and serum nesfatin-1 level (4.32±1.72 versus 5.83±1.51 mmol/L) compared to T2DM patients without microvascular complications. This evidence concerns the gene NUCB2 and type 2 diabetes mellitus.