Our study revealed that T2DM patients with microvascular complications had a statistically significant higher duration of diabetes, BMI, waist circumference, systolic and diastolic blood pressure, serum creatinine, UACR, serum urea, TC, TG, LDL cholesterol, fasting plasma glucose, and postprandial plasma glucose, while they had statistically significant lower eGFR, HDL cholesterol, and serum nesfatin-1 level compared to healthy controls. The gene discussed is NUCB2; the disease is diabetes mellitus.