Additionally, serum Nesfatin-1 levels may have predictive value for the early detection of Type 2 T2DM patients, diabetic microvascular complications, and DKD at cut-off values of < 8.09 mmol/L, < 5.87 mmol/L, and < 5.46 mmol/L, respectively. This evidence concerns the gene NUCB2 and diabetic kidney disease.