F2 and Disseminated intravascular coagulation: D-dimer >0.5 mg/mL. High D-dimer level. Features of a pro-coagulant state and/or disseminated intravascular coagulation (DIC) include elevated lactate dehydrogenase levels, prolonged prothrombin and partial thromboplastin times, thrombocytopenia, and the occurrence of deep vein thrombosis or pulmonary embolism