Medications can also cause hyperkalemia by altering aldosterone signaling (e.g., non-steroidal anti-inflammatory drugs (NSAIDs) and angiotensin-converting enzyme (ACE) inhibitors), inhibiting sodium reabsorption in the distal convoluted tubule (e.g., potassium-sparing diuretics), or increasing the extracellular translocation of potassium (e.g., somatostatin and isoflurane). The gene discussed is ACE; the disease is Hyperkalemia.