Additionally, preclinical in vivo mouse models of TNBC tumor progression and metastasis were employed to substantiate our findings.<h4>Results</h4>The investigation revealed that the direct interaction between Kindlin-2 and β1-Integrin is mediated through the C-terminal F3 domain of Kindlin-2, while the interaction between Kindlin-2 and TβRI is facilitated through the F2 domain of Kindlin-2. The gene discussed is TGFBR1; the disease is neoplasm.