These proteins were selected based on their genetic link to PD, their presence in Lewy bodies, and/or being implicated in preclinical models of PD: (PINK1 (4, 11, 12, 20, 21), parkin (5, 11, 12), OGDH (11, 22), GBA (6, 8, 23), SOD1 (24, 25), and LRRK2 (7, 21) (Fig. 1a). The gene discussed is GBA1; the disease is Parkinson disease.