PRKN and Parkinson disease: These proteins were selected based on their genetic link to PD, their presence in Lewy bodies, and/or being implicated in preclinical models of PD: (PINK1 (4, 11, 12, 20, 21), parkin (5, 11, 12), OGDH (11, 22), GBA (6, 8, 23), SOD1 (24, 25), and LRRK2 (7, 21) (Fig. 1a).